“Action without knowledge and knowledge without action means wasted
resources and missed opportunities” –Dr. J. W. Lee, WHO Director General
The know-do gap is the chasm between what is known and what is done in
practice. Dr. Paul Farmer frames the
know-do gap in terms of infectious disease in saying,
“Simultaneously, rising life expectancy and rapid social change have
led to an increasing burden of chronic diseases for which we have effective
therapies but inadequate innovation for delivering them efficiently to the
neediest people–the so-called know-do, or delivery gap” (Farmer, 2013).
This is a fundamental
challenge in global health and reducing the global burden of disease. Though this is a fundamental challenge, it also
provides the greatest opportunity for strengthening of health systems.
The gap exists from research and policy to practice as well as the gap
between knowledge and awareness to action and behavior change. Eliminating this gap would mean eliminating preventable
deaths. It is estimated that two-thirds of
child deaths worldwide could be prevented by available, effective and cheap
interventions. The World Health
Organization estimates that 85.34% of the global disease burden is addressable
by already available and cost effective interventions. This is huge.
If this is the case, why isn’t this being done? Why is this still such an enormous problem?
The challenge remains to synthesis existing knowledge and disseminate
this knowledge appropriately. There is
a wealth of information that exists on the Internet, but policy makers, health
managers, and service providers are not receiving succinct and synthesized
information. Grimshaw et al. (2004) stated
in a review that assessed guideline dissemination and implementation strategies
that “despite 30 years of research in this area, we still lack a robust,
generalisable evidence base to inform decisions about strategies to promote the
instruction of guidelines or other evidence-based measures into practice” (Grimshaw
et al., 2004).
Furthermore, care delivery is messy. It isn’t easily studied with a
randomized-controlled trial – there are too many variables, too many potential
confounders. This is especially true in impoverished settings with endemic
inequality. Developing effective care delivery strategies requires
observational and qualitative methods and establishing cultural understandings.
Despite all of these obstacles, it remains fundamentally true that all our
research is for naught if we don’t actually help anyone with it. Isn’t that why
we all want to be in global health in the first place anyway?
Policy
memos are a tool for bridging the knowledge gap between research and
policy. When done correctly, policy
memos provide a concise and comprehensive account a specific problem with an
impactful, feasible, cost effective solution.
Yet, policy memos are only one example of the implementation of public
health research. For a new intervention, vaccine, or service to alleviate
disease to be effective it must be addressed systematically through policy and
programs and services to implement the latest scientific data into patient
care.
One of the most poignant examples of the power of care delivery has
been the President’s Emergency Plan for AIDS Relief (PEPFAR). PEPFAR was able to
do what many thought couldn’t be done - treat
a chronic infection with a multidrug regimen poor settings. PEPFAR has made
huge strides to diagnose HIV disease, enroll patients, and thus bridge the
know–do gap and have a real effect on patients’ lives. Worries about patients
in low-income settings ability to follow complex multidrug regimens have been
proven surmountable. Dr. Farmer estimated that “in Haiti and Rwanda, so too in
South Africa, Kenya, Tanzania, Uganda, Mozambique, and across the continent: more
than 7.1 million Africans — nearly half of those who would most benefit from it
— are now receiving ART; an estimated 700,000 deaths and more than 200,000
perinatal infections were averted in 2010 alone” (Farmer, 2013). The success in
the global effort to combat HIV/AIDS shows what can be done when the know-do
gap is addressed effectively and systematically.
The solution lies in figuring out a path to action for each unique
situation and replicating a model to scale up.
In order to reduce the know-gap, we must focus on knowledge translation. We must bring together information from
entrepreneurs, basic research and innovation and operations research, and
synthesize results to scale up and allow for continuous improvement. Knowledge translation strategies can
harness the power of scientific evidence and leadership to inform and transform
policy and practice.
If you’re interested in learning more about the know-do gap, why it is
so problematic, and what has been done to address it, read Dr. Farmer’s article
in the New England Journal of Medicine,
“Chronic Infectious Disease and the Future of Health Care Delivery.”
The effectiveness of PEPFAR and the Global Fund’s efforts to fight
HIV/AIDS was accomplished because of advocacy efforts to overcome the delivery
gap. Now, we must engage in advocacy efforts for other disease burdens to
develop care delivery systems and meet real need. Doing science isn’t enough.
If our work is to have any real impact, we must figure out how to apply it to
the lives of those suffering from disease around the world.
Farmer, P. E. (2013). Chronic Infectious Disease and the Future of
Health Care Delivery. New England Journal of Medicine, 369(25), 2424–2436.
http://doi.org/10.1056/NEJMsa1310472
Grimshaw, J., Thomas, R., MacLennan, G., Fraser, C., & Ramsay, C. (2004). Effectiveness and efficiency of guideline dissemination and implementation strategies. Health Technology Assessment, 8(6), 84. http://doi.org/10.3310/hta8060
Grimshaw, J., Thomas, R., MacLennan, G., Fraser, C., & Ramsay, C. (2004). Effectiveness and efficiency of guideline dissemination and implementation strategies. Health Technology Assessment, 8(6), 84. http://doi.org/10.3310/hta8060
Thanks, Michelle and Alex, for sharing your thoughts on this complex problem of closing the know-do gap. I think you have touched on arguably the biggest barrier to implementing effective policy and strategy to reduce health discrepancies: disseminate knowledge appropriately. I whole-heartedly agree that policy makers and managers are not able to easily gather the necessary information for policy making because of an oversaturation of available data. In my eyes, this is probably the largest obstacle to overcoming the know-do gap because it is completely unfeasible for policy makers to (1) stay up to date with all of the available research, (2) summarize the net results of multiple studies, and (3) appropriately evaluate conflicting claims. As you mention, policy memos are one way of achieving this, but I feel that more often than not, even these may not accurately embody the wealth of knowledge available. Once actions are taken to address these logistic problems, I think more effective actions may be taken to close the gap.
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ReplyDeleteIt is great to know that there is some light being shed on the know-do gap, and addressing that there is a real problem in the knowledge getting to the masses in ways that are digestible and meaningful is the first step in closing this gap. The challenges of our age will only be solved when the knowledge that exists among the policy makers, scientists, affected individuals meet in one central location.
ReplyDeleteI believe that one of the reasons why the know-do gap exists is that despite knowing the technical solutions to some global health problems, it is still unclear how to best implement these solutions. If there is one thing I learned in 701, it is that global health issues are multifaceted. Even if there are effective solutions to health problems, it is difficult to know how to translate knowledge into action in the real world, where, even if there are funding and infrastructure to support the proposed interventions, there are still factors such as politics, culture, and personal circumstances that may prevent the intervention from reaching the full intended impacts. In a TED talk, Esther Duflo, Professor of Economics at MIT and Cofounder and Director of JPAL, calls the know-do gap by a different name: the Last Mile Problem. She suggests that implementation science is the key to bridging the gap. In the era where there is access to an overwhelming number of published research, implementation science helps policymakers understand the effectiveness of each in the real world, outside of the clean, regulated environment of the RCTs. Compared to RCTs, implementation research is more difficult to conduct because it is less controlled and requires a scale up of interventions, thus requiring more personnel and funds. Though it is an emerging, and arguably one of the more difficult fields in global health, I believe that translational research is the crucial aspect to bridging the know-do gap, and that only by accelerating progress in this field can we finally cross the Last Mile.
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ReplyDeleteThanks for the blog. I have taken a course called medical anthropology in which we talked about Dr. Farmer's engagement in South America. I believe he is indeed a good example for filling the know-do gap. Know-do gap is regularly discussed in global health fields and many students (including me) have confusions about it. I think sometimes people feel uncertain about this is because they have not acquired enough field experiences. That's why I like the way global health institute trains us. We have plenty time and opportunities to figure what we are interested in and acquire some real work practices. I also like the policy memo part in the blog. The process to write a policy memo is torturing, though.
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